The pleiotropic benefits of statins

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August undefined, 2024

WebbMost pleiotropic effects of statins in cell cultures can be reversed by the addition of mevalonate. Effects that are mediated by Rho GTPases are attributed to the isoprenoid, … WebbAccumulating evidence have suggested that statins, in addition to LDL-C lowering, exhibited properties of plaque stabilization and endothelial homeostasis; anti …

JCI - Isoprenoids as mediators of the biological effects of statins

Webb19 apr. 2010 · This article is part I of a 2-part review, and it focuses on the pleiotropic effects of statins at the cellular level. References. Buhaescu I., Izzedine H. Mevalonate pathway: a review of clinical and therapeutical implications . ... Statins: Risk-Benefits and Role in Treating Dyslipidemias. WebbBeneficial Cardiovascular Pleiotropic Effects of Statins Jean Davignon, MD Abstract—Pleiotropic effects of a drug are actions other than those for which the agent … impot traduction

Pleiotropic Effects of Statins on the Cardiovascular System

Webb8 apr. 2024 · The greatest improvements were recorded in the fluvastatin and dual therapy groups, suggesting the statin had played a dominant role. 28 Remarkably, a significant increase in nitric oxide and reduction in endothelin-1 was observed in the two groups receiving statins, indicating that the pleiotropic effects of this drug are fundamental for … Webb22 apr. 2024 · More than 35 million Americans take statins, most of whom are prescribed Atorvastatin being one of the most popular prescription drugs of its kind. Here are some of the many benefits of taking Atorvastatin medication for patients:. Taking Atorvastatin benefits the body’s cholesterol levels.; Atorvastatin works primarily by reducing low … WebbAlthough some trials evaluating the effects of statins on kidney disease outcomes have shown benefits of statins, 16,17,33 others have shown no effect. 18,34,35 However, most of these studies ... Dhawan V, Sharma PL, Kumar P. Pleiotropic effects of statins: new therapeutic targets in drug design. Naunyn Schmiedebergs Arch Pharmacol. 2016;389(7 ... lithamin plus

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The pharmacology of statins. Semantic Scholar

WebbThis paper builds on these findings and presents practical guidance for maximising the pleiotropic benefits of this class of medicines in people with T2DM in terms of reducing adverse CVD outcomes. The Improving Diabetes Steering Committee aims to offer evidence-based practical guidance for the use of SGLT2i therapies in people with T2DM … Webb6 jan. 2024 · Pleiotropic Effects of Statins on the Cardiovascular System. The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary … lithamine greenvetWebbInhibition of protein prenylation for proteins such as RhoA (and subsequent inhibition of Rho-associated protein kinase) may be involved, at least partially, in the improvement of … lithamine chien rcp

"Webb1 okt. 2012 · In recent years, however, a number of additional non-lipid-lowering, or ‘pleiotropic’, effects of statins have been suggested to contribute to their efficacy in … " - The pleiotropic benefits of statins

The pleiotropic benefits of statins

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Webb31 dec. 2024 · Other Advantages of Statins. One of the most interesting truths about statin drugs is actually not related to cholesterol at all. Statins are anti-inflammatories. This is called a pleiotropic effect, i.e. a beneficial effect outside of what was expected. Webbför 6 timmar sedan · select article The pleiotropic effects of high-density lipoproteins and apolipoprotein A-I. https: ... select article The advantages and pitfalls of genetic analysis in the diagnosis and management of lipid disorders. ... Statins and diabetes: What are the connections? Naveed Sattar. Article 101749 View PDF.

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WebbThe cardiovascular risk benefits as well as the potential pleiotropic benefits of statins warrants strong consideration of use of statin therapy in patients with cirrhosis. Although 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (‘statins’) reduce the risk of cardiovascular events, fears about hepatotoxicity have historically led to underuse in … Webb20 maj 2024 · One of the factors to be considered when evaluating outcomes of lipid-lowering treatment with statins is their solubility. Therefore, the role of both hydrophilic …

Webb6 maj 2016 · These may be predicted as harmful or beneficial effects of the drug. The most wonderful positive pleiotropic effects of statins are anti-inflammatory, anti-proliferative, antithrombotic, improving endothelial dysfunction, and neuroprotective besides many others (Lewington et al. 2007; DuBroff and De Lorgeril 2015 ). WebbPleiotropic effects of statins include improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory responses, …

Webb7 apr. 2024 · Request PDF The pleiotropic effects of statins in rheumatoid arthritis Objectives: Rheumatoid arthritis (RA) is an inflammatory and autoimmune disease. Studies over the past two decades ... Webb1 apr. 2002 · These agents appear to reduce bone fractures and may improve insulin sensitivity and reduce the likelihood of persons progressing from impaired glucose …

Webb30 nov. 2024 · Of note, statin treatment possesses the ability to make an immediate impact in patient care. Clinical trials with statins reveal conflicting results, but overall …

Webb27 okt. 2016 · Individualized Statin Benefit for Determining Statin Eligibility in the Primary Prevention of Cardiovascular Disease. Circulation. 2016 Apr 19;133(16):1574-81. Robinson JG, Ray K. Moving Toward the Next Paradigm for Cardiovascular Prevention. Circulation. 2016 Apr 19;133(16):1533-6. impot torcyWebbPitavastatin has been shown to have similar pleiotropic effects to other statins, including decreasing platelet activation and improving cardiac and endothelial function. 32 Thus, it … impot trop payeWebbCurrently, new benefits of statins, not dependent on the reduction of LDL cholesterol, have been proposed in the setting of ACS. These effects, which are not dependent on the reduction of LDL cholesterol, are called pleiotropic [Liao, 2005]. Some of the possible effects of statins, which may participate in the benefits that they represent for impot ts1Webb15 mars 2024 · Ultimately, the benefits of statins in an infection setting appear to require attention to the underlying host response and to the timing of the dosage. From this … litham veilWebbIndeed, recent studies indicate that some of the cholesterol-independent or “pleiotropic” effects of statins involve improving endothelial function, enhancing the stability of … lithana guidanceWebb1 juni 2004 · These non-lipid-lowering (pleiotropic) effects of statin therapy are believed to include antiinflammatory actions, property to reverse endothelial dysfunction by decreasing LDL oxidation and increasing nitric oxide bioavailability. lithanWebb30 apr. 2024 · This misconception, and therefore reluctance to prescribe statins, may indirectly deny patients with chronic liver disease significant clinical benefit (Fig. 1).Unrelated to its lipid-lowering effects, statins have a wide array of pleiotropic effects, ranging from antioxidant, antifibrotic, anti-inflammatory, and improvement of endothelial … litha mythology