Web12. apr 2024 · Periportal vacuolar degenerative changes of hepatocytes with pyknotic nuclei and Kupffer cell proliferation were noted. There was nuclear loss or binucleated hepatocytes. Web1. mar 1992 · Periportal to perivenous gradients of oxygen, hormones and metabolites, as well as zonal differences in the hepatic innervation, seem to be responsible for the heterogeneous gene expression within the liver acinus. liver cell heterogeneity, liver zonation, hepatocytes Topic: heterogeneity hepatocytes hepatic acinus Issue Section:

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WebRelated to the maintenance of ammonia in the liver, hepatocytes play a key role in scavenging the cation by either: (i) the action of CPS1 from the urea cycle in the periportal region or (ii) the GLUL-mediated glutamine synthesis in the perivenous region . WebHepatocyte preparations highly enriched in cells from either the periportal or the perivenous zone of the liver acinus were prepared using a digitonin/collagenase perfusion method. … can lipitor cause kidney pain

Impact of Alcohol on Glycemic Control and Insulin Action

Web24. aug 2024 · Periportal hepatocytes (PPHs) and perivenous hepatocytes (PVHs) in standard optical microscopy appear to be morphologically identical. However, the functional properties of these two cell populations and their roles in liver lobules are not the same. Despite significant differences in gene expression between these two hepatocyte … Web1. mar 1992 · Abstract. Periportal hepatocytes around the afferent vessels and perivenous hepatocytes around the efferent vessels of the liver acinus exhibit different metabolic … WebMany studies indicate that chronic alcohol intake decreases whole liver glycogen content [47,48,49] which occurs in both periportal and perivenous hepatocytes , and is consistent with the observed reduction in basal glycogen synthase activity. can lipitor cause memory loss and confusion