WebDec 1, 2024 · CCCTC-binding factor (CTCF) is known to anchor loops and construct 3D genomes, but how anchor sites are selected is not yet understood. Here, we unveil Jpx RNA as a determinant of anchor selectivity. Jpx RNA targets thousands of genomic sites, preferentially binding promoters of active genes. Depleting Jpx RNA causes ectopic … WebApr 10, 2024 · CTCF expression was upregulated with effector T cell differentiation, with greater induction observed in the Klrg1 hi population by scRNA-seq at day 7 (Figure 2 …
CTCF Gene - GeneCards CTCF Protein CTCF Antibody
WebSmits et al. report that TLX3 chromosomal translocations in T cell acute lymphoblastic leukemia patients recurrently include intervening CTCF-binding sites in the breakpoint area. Pressure to acquire inactivating aberrations in CTCF abrogate consequential enhancer insulation that promotes TLX3 promoter to BCL11B enhancer looping boosts higher … WebApr 10, 2024 · Introduction. In response to T cell receptor (TCR)-mediated recognition of antigens, naive CD8 + T cells rapidly proliferate and acquire cytotoxic and cytokine-producing effector functions to provide protection from infections and tumor growth. Although the majority of effector CD8 + T cells become terminally differentiated and die following … dhc cash dropper
CTCF - Wikipedia
WebFurther, patients with de novo CTCF mutations had reduced expression of the terminal-effector genes in peripheral blood lymphocytes. Therefore, in addition to establishing … WebCurrent epigenomics approaches have facilitated the genome-wide identification of regulatory elements based on chromatin features and transcriptional regulator binding and have begun to map long-range interactions between regulatory elements and their targets. Here, we focus on the emerging roles of CTCF and the cohesin in coordinating long … WebMay 21, 2024 · Author summary Human T-cell leukemia virus type 1 (HTLV-1) is a cause of leukemia and lymphoma as well as several inflammatory medical disorders. The virus integrates in the host cell DNA, and it has a single binding site for a protein designated CTCF. This protein is important in the regulation of many DNA viruses, as well as many … dhc bottoms