WebMay 17, 2024 · Four ER-resident proteins (FAM134B, CCPG1, SEC62, and RTN3) have been identified as ER-resident cargo receptors, which contain LC3-interacting regions. In this study, we identified an N … Highly specific and rigorously validated in-house, FAM134B (E8Y9R) Rabbit Monoclonal Antibody (CST #83414) is ready to ship. ... FAM134B (family with sequence similarity 134, member B), also referred to as JK-1 and RETREG1, is a cis-Golgi endoplasmic reticulum (ER) transmembrane protein that plays a role in ER homeostasis and may contribute to ...
FAM134B induces tumorigenesis and epithelial‐to‐mesenchymal …
WebAug 24, 2024 · Several ER surface receptors, including FAM134B, reticulon 3L (RTN3L), Sec62, and CCPG1, have been shown to contain conserved LC3-interacting regions (LIRs) that can act as specific autophagy receptors to allow portions of the larger ER network to be shunted to core autophagy pathways ( Khaminets et al., 2015; Fumagalli et al., 2016; … WebJan 13, 2024 · FAM134B forms oligomers that are required for ER membrane scission and ER-phagy A. Endogenous FAM134B forms oligomers. FAM134B knockout (KO) or wild-type (WT) 293T cells were treated with 1 μM of Thapsigargin (Tg) for different time, and the cell lysates were prepared and analyzed by Western blot. can potatoes help with constipation
FAM134B Attenuates Seizure-Induced Apoptosis and …
WebJun 15, 2024 · FAM134B is a member of the reticulon-homology-domain-containing FAM134 family and is mainly localized to the edges of the ER sheets. FAM134B binds MAP1LC3B via its LC3 interacting region (LIR) and at the same time to fragmented ER sheets and coalesces them into vesicles, which are subsequently degraded by lysosomes. WebJul 8, 2024 · The endoplasmic reticulum (ER) autophagy receptor FAM134B contains an LIR motif that can bind to Atg8s, but whether it can differentially bind to the two … flame wheel tree