WebICC/IF image of ab53156 staining Claudin 4 (green) in MCF7 (Human breast adenocarcinoma cell line) cells. The cells were fixed in 4% formaldehyde (10 minutes) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1 hour to permeabilize the cells and block non-specific protein-protein interactions. The … WebJul 23, 2024 · The claudin-family proteins are a group of tight-junction membranous proteins responsible for paracellular molecular flow between adjacent cells of the epithelium. 1 In normal kidney, claudin-4 plays a key role in paracellular ion reabsorption. 2 Claudin-4 is expressed in most epithelial cells yet is absent in mesothelial cells, making it of great …
Claudin‐4 immunohistochemistry is highly effective in …
WebAug 1, 2024 · Objectives: Claudin-4 is aberrantly expressed in nearly 70% of all ovarian cancer tumors, and increased claudin-4 expression conveys a worse overall survival. Poly (ADP-ribose) polymerase (PARP) inhibitors are a therapeutic option for patients with ovarian cancer. PARP inhibitors exploit deficiencies in DNA damage repair (e.g., BRCA … WebBrief Fact Summary. After a probate court disapproved a will in which Bull (Defendant) was named as a beneficiary, allowing Calder (Plaintiff)) to inherit instead, the state legislature … theory cashmere sweater sale
Claudin‐4 immunohistochemistry is highly effective in
WebThe tight junction protein claudin-4 has been reported to be overexpressed in advanced ovarian cancer. We investigated the prognostic significance of claudin-4 overexpression and whether claudin-4 ... WebSep 1, 2015 · Neville MC, Webb PG, Baumgartner HK, Bitler BG. Claudin-4 localization in epithelial ovarian cancer. Heliyon. 2024 Oct; 8(10):e10862. PMID: 36237976. ... Ovarian … WebJan 13, 2014 · Claudin-4 is a tight-junction-associated protein that is expressed in most epithelial cells but is absent in mesothelial cells. 12 Immunohistochemistry for claudin-4 has recently been shown to distinguish adenocarcinoma from malignant mesothelioma with high sensitivity and specificity, mostly in surgical specimens. 13-18 Our aim was to validate ... shrubby hare\\u0027s ear plant